PARP inhibitors: what are they? What are their uses, how do they work, and how can they be used

What is a PARP inhibitor?

A type of cancer drug is PARP inhibitors. Poly adenosine diphosphate-ribose polymerase (PARP) is a type of enzyme that aids in the repair of DNA damage in cells.PARP inhibitors stop cancer cells from mending themselves, allowing them to perish. Targeted therapy is what these medications are. They mostly attack cancer cells while avoiding healthy cells. The uses of PARP inhibitor targeted therapy are discussed below. We also go over the adverse affects and other things to think about.

What is a PARP inhibitor?

A PARP inhibitor is a prescription medication that aids in the treatment of certain cancers. PARP enzymes in cells are inhibited by it.

PARP enzymes are involved in DNA repair. Cancer cells can't repair themselves if they're blocked, thus they die.

PARP inhibitors are divided into four groups:

rucaparib (Rubraca) talazoparib (Lynparza) niraparib (Zejula) olaparib (Lynparza) niraparib (Zejula) niraparib (Zejula) niraparib (Zejula) ni (Talzenna)

How do they function?

PARP inhibitors prevent the PARP enzymes PARP-1, PARP-2, and PARP-3 from working. All of these things aid in the repair of damaged DNA in cells.

PARP inhibitors prevent cancer cells from mending themselves, and if they are unable to repair themselves, they die.

These medications selectively target cancer cells, and manufacturers are presently working on new PARP inhibitors that may better target tumour cells.

Uses

PARP inhibitors have been approved by the Food and Drug Administration (FDA) for use in cancer treatment.

Adults with BRCA 1 or 2 mutations and metastatic breast cancer may be prescribed talazoparib by their doctor.

Rucaparib is used to treat cancers of the ovary, fallopian tube, primary peritoneum, and prostate. Doctors may use it if other therapies, like as chemotherapy, have failed or during the post-chemotherapy maintenance period.

Niraparib is used to treat ovarian cancer, fallopian tube cancer, and primary peritoneal cancer in the same way that rucaparib is used to treat prostate cancer.

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